Sepanik is the project director of the Next Generation California Partnership Academies study, a rigorous evaluation of career academies; the Diplomas Now Investing in Innovation evaluation, an impact study of a secondary school reform model; and an evaluation of the Oregon Early Indicator and Intervention System, a quasi-experimental study of a statewide early warning system. She has been involved in several other evaluations during her tenure at MDRC, including the Advancement Via Individual Determination (AVID) Central Florida Collaborative evaluation, the evaluation of the Dana Center Mathematics Pathways, the Enhanced Reading Opportunities impact study, professional development impact studies for second-grade reading teachers and seventh-grade math teachers, the evaluation of the Formative Assessments of Student Thinking in Reading program in Boston Public Schools, the Getting Ready for Success college-readiness pilot project in Tacoma, Washington, and an exploratory study of college-readiness partnerships in Texas. She has been responsible for running site and student recruitment efforts, managing quantitative and qualitative data collection, designing surveys and interview protocols, analyzing program effects, and coauthoring several reports. Before joining MDRC, Sepanik worked as a research intern at Chicago Public Schools, conducting research on student access to quality teaching and supporting efforts to create a school accountability system for the district. She has also taught middle school language arts and social studies. She has an MPP from the Harris School for Public Policy at the University of Chicago.